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Sepragen Grants a Temporary License to Tropicana Products, Inc

HAYWARD, CA, May 31, 1998 - Sepragen Corporation (OTC BB: SPGNU, SPGNA, SPGNW) announced today that it had granted a temporary license to Tropicana Products, Inc., for the evaluation of its technology, equipment, and patent-pending process to remove the bitterness and acidity from grapefruit juice.

The process, called SepraDebittâ„¢, utilizes Radial Flow Chromatography (RFC) to remove the compounds responsible for citrus juice bitterness to very low levels. According to the company, the process also has significantly higher capacity per cycle and several times the throughput of the nearest commercial process.

Since its founding in 1985, Sepragen has been developing and manufacturing liquid chromatography systems primarily for the biopharmaceutical industry. Recently, it has applied its expertise in large-scale separation to develop faster, more efficient separation for processes in the beverage, dairy, food, brewing, and environmental industries.

Chromatography is a chemical separations technology that results in higher purity separation than filtration. Chromatography is performed in tubular columns containing chemically coated porous beads. A liquid mixture containing the target molecules is pumped through the separations media to a collection channel at the bottom of the column. As the mixture flows through the column, only the target molecules bind to the surface of the separations media. Because the binding is chemical, not based on size, the separation process is exact and the resulting purity of the end product is high.

There are two types of liquid chromatography - axial and radial flow. In axial flow a liquid mixture is pumped vertically through the tubular column. This method is adequate where small amounts of liquid are involved but presents problems in scale-up. In Radial Flow Chromatography the flow of liquid is laterally from a sleeve surrounding a permeable column to a hollow cylinder at the center. (See picture left.) Flow rates through the column are substantially higher, allowing economical processing of large volumes of material.

According to Vinit Saxena, founder, president, and CEO of Sepragen and RFC developer, "Larger cross-sectional areas make the flow path shorter, resulting in higher flow rates and more overall productivity."

Orange processing in both California and Florida results in unsqueezed juice that is too bitter to use. Additionally, oranges grown in California go through a period of months when they are too bitter to be processed into juice. If processors could use all of the juice in the orange, not just that obtained in the first squeeze, improvement in economics would be considerable.

According to Saxena, "Orange processing today is inefficient and a meaningful portion of the juice is simply too bitter to use. By increasing yields, improving quality, and quite possibly increasing consumption of its products, we believe Sepragen's SepraDebittâ„¢ process can add significant value to citrus juice growers and processors." .

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The statements in this release that relate to future events or performance, statements about growth, future regulatory clearances, levels of sales and market size and future manufacturing capacity and efficiencies are forward-looking statements that involve risks and uncertainties, including risks associated with uncertainties related to the development of markets for and commercial acceptance of the company's products and services, the availability of components, competitors' product introductions and other risks identified in the company's SEC filings. Actual results may differ from those described in these forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof.


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